Stem cell highways: signalling beats trafficking?

After the oocyte is fertilized, the resulting one-cell zygote gives rise to all stem cell progenies. During the developmental process, these cells are necessary to generate all specialized tissues. However, some of them elude the specification cues and remain quiescent in the adult tissue, as long as the organism does not suffer from injury, illness, or specific cell-type depletion. Most adult ...

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Hematopoietic stem cell trafficking

Hematopoiesis is sustained by a renewable pool of stem cells that interacts with distinct, sequential and specific microenvironments during normal development and throughout adult life. Hematopoietic stem cells (HSCs) are unique in their ability to migrate to various sites, ensuring the safety and integrity of their regenerative potential. This review is focused on the guidance cues and molecul...

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Membrane Trafficking: Intracellular Highways and Country Roads

Membrane trafficking, or the flow of membrane material between endomembrane compartments and the plasmalemma, is essential for transport of proteins and other macromolecules to various destinations inside and outside of the cell. Membrane trafficking also underlies the fundamental need for cells to maintain cellular homeostasis, as well as to meet specific demands during signal perception and t...

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Membrane trafficking: intracellular highways and country roads.

Membrane trafficking, or the flow of membrane material between endomembrane compartments and the plasmalemma, is essential for transport of proteins and other macromolecules to various destinations inside and outside of the cell. Membrane trafficking also underlies the fundamental need for cells to maintain cellular homeostasis, as well as to meet specific demands during signal perception and t...

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Membrane Trafficking: Intracellular Highways and Country Roads

Membrane trafficking, or the flow of membrane material between endomembrane compartments and the plasmalemma, is essential for transport of proteins and other macromolecules to various destinations inside and outside of the cell. Membrane trafficking also underlies the fundamental need for cells to maintain cellular homeostasis, as well as to meet specific demands during signal perception and t...

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Stem cell highways: signalling beats trafficking?

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